Characterization of the sensitivity to various genotoxic agents of the UVU1-CHO cell line, a double mutant from UV complementation group 1.
作者信息
Lesca C, Vispé S, Defais M
机构信息
Institut de Pharmacologie et Biologie Structurale, CNRS, UPR 8221, Toulouse, France.
出版信息
Biochimie. 1997 May;79(5):261-3. doi: 10.1016/s0300-9084(97)83513-4.
PMID:9258434
Abstract
The UVU1 CHO cell line, a double mutant of the excision repair complementation group 1 UV4 cell line was characterized by a higher UV sensitivity than its parent (Busch et al (1989) Mutagenesis 4, 349-354). We show here that this mutant is not affected in a UV mutagenic pathway. In addition, the UVU1 cell line is about two-fold more sensitive to N-methyl-N'-nitro-N-nitrosoguanidine treatment than its parent without being more sensitive to cross-linking agents or ionizing radiations.
摘要
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