Delahaye M, van der Ham F, van der Kwast T H
Department of Pathology, Erasmus University, Rotterdam, The Netherlands.
Diagn Cytopathol. 1997 Aug;17(2):115-20. doi: 10.1002/(sici)1097-0339(199708)17:2<115::aid-dc6>3.0.co;2-f.
Cytological slides of serous fluids of 41 malignant mesotheliomas, 88 metastatic adenocarcinomas, and 25 reactive effusions were immunostained with the antibodies anti-CEA, MOC-31, Leu-M1, Ber-EP4, and B72.3. Most mesotheliomas and all reactive fluids failed to stain with these antibodies. The sensitivity of the five markers to detect carcinoma cells differed remarkably. Especially MOC-31, Ber-EP4, and B72.3 stained with a high number of carcinoma cases and the complemetary value of Ber-EP4 and B72.3 to immunostain carcinoma cells was impressive: 94% of the metastatic adenocarcinoma cases reacted with Ber-EP4 or B72.3 in contrast to 1 of 41 malignant mesotheliomas.
对41例恶性间皮瘤、88例转移性腺癌和25例反应性积液的浆液进行细胞学涂片，用抗CEA、MOC - 31、Leu - M1、Ber - EP4和B72.3抗体进行免疫染色。大多数间皮瘤和所有反应性积液对这些抗体均无染色。这五种标志物检测癌细胞的敏感性差异显著。尤其是MOC - 31、Ber - EP4和B72.3在大量癌病例中呈阳性染色，且Ber - EP4和B72.3对癌细胞免疫染色的互补价值令人印象深刻：94%的转移性腺癌病例与Ber - EP4或B72.3反应，而41例恶性间皮瘤中仅有1例出现这种情况。
