Wright C A, Nayler S J, Leiman G
Department of Anatomical Pathology, School of Pathology, South African Institute for Medical Research, Johannesburg, South Africa.
Diagn Cytopathol. 1997 Aug;17(2):138-42. doi: 10.1002/(sici)1097-0339(199708)17:2<138::aid-dc10>3.0.co;2-h.
Follicular dendritic cell tumors are rarely described entities, arising from antigen-presenting immune accessory cells, found within B-lymphocyte follicles in nodal and extranodal sites. We report two cases, one associated with Castleman's disease, in whom fine-needle aspiration biopsy was performed followed by surgical biopsy. The diagnosis was confirmed using immunoreactivity with CD21 and CD35 antibodies and by ultrastructural demonstration of interdigitating cell processes with desmosomes. Both the cytologic and histologic findings are presented, and the differential diagnoses are discussed. Awareness of this entity and recognition of the pathologic features may lead to a presumptive diagnosis which must be confirmed using imunohistochemistry and/or electron microscopy.
滤泡树突状细胞瘤是一种罕见的肿瘤，起源于抗原呈递免疫辅助细胞，见于淋巴结和结外部位的B淋巴细胞滤泡内。我们报告两例病例，其中一例与Castleman病相关，均进行了细针穿刺活检，随后进行了手术活检。通过与CD21和CD35抗体的免疫反应性以及具有桥粒的指状细胞突起的超微结构证实了诊断。本文展示了细胞学和组织学检查结果，并讨论了鉴别诊断。认识到这一实体并识别其病理特征可能有助于做出初步诊断，但必须通过免疫组织化学和/或电子显微镜检查加以证实。
