Genovesi S, Pieruzzi F, Centonza L, Wijnmaalen P, Zanchetti A, Stella A
Istituto di Clinica Medica Generale e Terapia Medica, University of Milan, Ospedale Maggiore, Italy.
J Auton Nerv Syst. 1997 Jul 14;65(1):45-8. doi: 10.1016/s0165-1838(97)00033-7.
To verify the existence of ipsilateral reno-renal reflexes we studied the effect of surgical denervation of one kidney on the ipsilateral efferent renal nerve activity (ERNA), in the absence of contralateral afferent renal nerve activity. Thus the ipsilateral renal denervation was performed 1 h later than the contralateral renal denervation. The experiments were done on 9 anesthetized cats. Arterial pressure, urine flow rate (UFR) of both kidneys and ERNA to the ipsilateral kidney were measured. All variables were monitored during a 3 min control period and for 13 min after either contralateral and ipsilateral renal denervations. ERNA significantly increased (+20 +/- 9%) and UFR concomitantly decreased (-11 +/- 10%) after the surgical denervation of the contralateral kidney which showed an increase (+91 +/- 19%) in UFR. The subsequent ipsilateral denervation caused a significant increase in UFR (+117 +/- 25%) and ERNA (79 +/- 23%) of the same kidney, while on the opposite side UFR did not change. During the two procedures, arterial pressure did not change. Our data demonstrate the existence of ipsilateral reno-renal reflexes that exert a tonic inhibitory effect on ipsilateral ERNA.
为了验证同侧肾-肾反射的存在，我们研究了在对侧肾传入神经活动缺失的情况下，一侧肾脏手术去神经支配对同侧肾传出神经活动（ERNA）的影响。因此，同侧肾去神经支配手术比另一侧肾去神经支配手术晚1小时进行。实验在9只麻醉猫身上进行。测量了动脉血压、双侧肾脏的尿流率（UFR）以及同侧肾脏的ERNA。在3分钟的对照期以及对侧和同侧肾去神经支配后的13分钟内，对所有变量进行监测。对侧肾脏手术去神经支配后，ERNA显著增加（+20±9%），同时UFR相应降低（-11±10%），而对侧UFR增加（+91±19%）。随后的同侧去神经支配导致同一侧肾脏的UFR显著增加（+117±25%）和ERNA增加（79±23%），而另一侧UFR没有变化。在这两个手术过程中，动脉血压没有改变。我们的数据证明了同侧肾-肾反射的存在，该反射对同侧ERNA具有紧张性抑制作用。
