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结节性硬化症患者研究中的磁化传递

Magnetization transfer in the investigation of patients with tuberous sclerosis.

作者信息

Girard N, Zimmerman R A, Schnur R E, Haselgrove J, Christensen K

机构信息

Department of Neuroradiology, Hopital Nord, Marseille, France.

出版信息

Neuroradiology. 1997 Jul;39(7):523-8. doi: 10.1007/s002340050459.

DOI:10.1007/s002340050459
PMID:9258933
Abstract

We examined 21 patients aged 5 months to 19 years, on a 1.5 T magnet. T1-weighted spin-echo images, proton density and T2-weighted images with spin-echo and turbo spin-echo sequences, and contrast-enhanced magnetization transfer (MT) T1-weighted images were obtained in all cases. MT T1-weighted images were performed before injection in 9 patients. Subependymal nodules were found in 14, and cortical and subcortical tubers in 20 of the 21 patients. MT T1-weighted images showed tubers and subependymal nodules as higher signal than normal gray matter and revealed more tubers than conventional sequences in 11 cases. High signal intensity lesions of the white matter were found in 19 patients but were seen only on MT images in 9 cases. When MT images both before and after injection were available, tubers and white matter lesions were more easily recognised on unenhanced MT images because of their higher contrast.

摘要

我们对21例年龄在5个月至19岁之间的患者进行了检查,使用的是1.5T磁体。所有病例均获取了T1加权自旋回波图像、质子密度以及采用自旋回波和快速自旋回波序列的T2加权图像,还有对比增强磁化传递(MT)T1加权图像。9例患者在注射前进行了MT T1加权图像检查。21例患者中,14例发现室管膜下结节,20例发现皮质和皮质下结节。MT T1加权图像显示结节和室管膜下结节的信号高于正常灰质,且在11例中发现比传统序列显示出更多的结节。19例患者发现白质高信号病变,但其中9例仅在MT图像上可见。当有注射前后的MT图像时,由于对比度更高,在未增强的MT图像上更容易识别结节和白质病变。

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