频繁复发的类固醇反应性肾病综合征中的持续性高胆固醇血症
Persistent hypercholesterolaemia in frequently relapsing steroid-responsive nephrotic syndrome.
作者信息
Tsukahara H, Haruki S, Hiraoka M, Hori C, Sudo M
机构信息
Department of Pediatrics, Fukui Medical School, Matsuoka, Japan.
出版信息
J Paediatr Child Health. 1997 Jun;33(3):253-5. doi: 10.1111/j.1440-1754.1997.tb01591.x.
OBJECTIVE
To investigate long-term changes of serum cholesterol levels in children with frequently relapsing steroid-responsive nephrotic syndrome (NS).
METHODOLOGY
Serum cholesterol values just before and during or immediately after 'relapse' were reviewed and the incidence of hypercholesterolaemia (> or = 200 mg/dL) was determined in eight patients (M:F, 6:2).
RESULTS
The patients with frequently relapsing NS usually showed hypercholesterolaemia (mean incidence, 81%) just before 'relapse' during clinical remission, as well as in relapse (mean incidence, 96%). A high incidence of steroid therapy was also found in each case (mean, 89%) just before relapse.
CONCLUSIONS
Our results demonstrate that children with frequently relapsing NS have prolonged periods of hypercholesterolaemia, even during clinical remission. It is suggested that serum lipid profiles be monitored carefully in such patients.
目的
研究频繁复发的激素敏感型肾病综合征（NS）患儿血清胆固醇水平的长期变化。
方法
回顾了“复发”前、复发期间或复发后即刻的血清胆固醇值，并确定了8例患者（男:女，6:2）高胆固醇血症（≥200mg/dL）的发生率。
结果
频繁复发的NS患者在临床缓解期“复发”前以及复发时通常表现为高胆固醇血症（平均发生率，81%），复发前每种情况中激素治疗的发生率也很高（平均，89%）。
结论
我们的结果表明，频繁复发的NS患儿即使在临床缓解期也有较长时间的高胆固醇血症。建议对此类患者仔细监测血脂情况。
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