Peculis B
Genetics and Biochemistry Branch, NIDDK, NIH, Bethesda, Maryland 20892, USA.
Curr Biol. 1997 Aug 1;7(8):R480-2. doi: 10.1016/s0960-9822(06)00242-9.
The functional role of a recently identified class of small nucleolar (sno) RNAs has been elucidated: the 'box H/ACA' snoRNAs act as guide RNAs, specifying the position of evolutionarily conserved pseudouridines in ribosomal (r)RNA via an rRNA-snoRNA base-pairing interaction that forms a 'pseudouridine pocket'.
最近发现的一类小核仁(sno)RNA的功能作用已得到阐明:“盒式H/ACA” snoRNA作为指导RNA,通过形成“假尿嘧啶口袋”的rRNA-snoRNA碱基配对相互作用,在核糖体(r)RNA中指定进化保守假尿嘧啶的位置。