用抗-D免疫球蛋白治疗自身免疫性血小板减少性紫癜：纯合子和杂合子Rh(D)阳性患者的血小板反应相似。
The treatment of autoimmune thrombocytopaenic purpura with anti-D immunoglobulin: similar platelet responses in homozygous and heterozygous Rh(D) positive patients.
作者信息
Smith N A, Boughton B J
机构信息
Department of Haematology, Queen Elizabeth Hospital, Birmingham, U.K.
出版信息
Transfus Med. 1991 Sep;1(3):183-5. doi: 10.1111/j.1365-3148.1991.tb00029.x.
Abstract
Twenty-one patients with autoimmune thrombocytopaenic purpura (AITP) were treated with anti-D immunoglobulin. There was no significant difference with low and high dose anti-D treatment in the platelet count response between homozygous and heterozygous Rh(D) positive patients. The heterogeneous responses seen in Rh(D) positive AITP patients treated with anti-D immunoglobulin cannot therefore be explained by differences in Rh(D) phenotypes.
摘要
21例自身免疫性血小板减少性紫癜（AITP）患者接受了抗-D免疫球蛋白治疗。在纯合子和杂合子Rh（D）阳性患者中，低剂量和高剂量抗-D治疗在血小板计数反应方面无显著差异。因此，用抗-D免疫球蛋白治疗的Rh（D）阳性AITP患者中观察到的异质性反应不能用Rh（D）表型差异来解释。
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