Williams R S, Kipersztok S, Hills D, Dattilo M
University of Florida, Gainesville, USA.
J Fla Med Assoc. 1997 Jun-Jul;84(5):316-9.
To determine the efficacy and cost of a simplified superovulation regimen compared with traditional control ovarian hyperstimulation with gonadotropins (HMG).
This was a retrospective study in a university referral center with 99 infertile couples undergoing 225 treatment cycles. The outcome was compared to outcomes of previously published studies. The simplified superovulation regimen included clomiphene citrate 100 mg on cycle days 5 through 9 and HMG 75 IU on cycle days 5, 7, 9, and 11, with estradiol and ultrasound monitoring on day 13. If adequate follicular maturity was documented, HCG 10,000 IU was administered, followed by intrauterine insemination 40 hours later.
Fecundity rates were assessed by life table analysis. Average cycle fecundity was 8%, with a cumulative rate of 29% over 4 cycles, compared to 10% monthly fecundity with HMG/IUI and background rates of 1 to 3%. Costs averaged $662 per cycle compared to $1,854 with HMG/IUI.
A simplified protocol of CC/HMG/ IUI is almost as effective as HMG/IUI and costs only one-third as much.
确定简化的超排卵方案与使用促性腺激素（HMG）的传统对照卵巢过度刺激方案相比的疗效和成本。
这是一项在大学转诊中心进行的回顾性研究，99对不孕夫妇接受了225个治疗周期。将结果与先前发表的研究结果进行比较。简化的超排卵方案包括在周期第5至9天服用100毫克枸橼酸氯米芬，在周期第5、7、9和11天服用75国际单位HMG，并在第13天进行雌二醇和超声监测。如果记录到卵泡充分成熟，则给予10000国际单位HCG，40小时后进行宫内人工授精。
通过生命表分析评估生育力。平均周期生育力为8%，4个周期的累积生育力为29%，而HMG/IUI的每月生育力为10%，背景生育力为1%至3%。每个周期的成本平均为662美元，而HMG/IUI为1854美元。
CC/HMG/IUI的简化方案几乎与HMG/IUI一样有效，成本仅为其三分之一。
