父亲的暴露因素与出生缺陷问题。

Paternal exposures and the question of birth defects.

作者信息

Poynor D H, Lupkiewicz S, Sage S R, Carver V H, Kousseff B G, Lubs H A, Williams C A

机构信息

Department of Pediatrics, University of Florida, Gainesville, USA.

出版信息

J Fla Med Assoc. 1997 Jun-Jul;84(5):323-6.

PMID:9260438

Abstract

Compared to maternal exposures, little attention has been paid to the possibility of paternally induced adverse effects on fetal development. There is increasing concern, however, about the potential for male-mediated developmental toxicity brought about by exposure to teratogenic agents. This is evidenced by the number of calls regarding paternal exposures that are received by teratogen information services. In this paper, we report the experience of the state of Florida's Teratogen Information Services regarding questions asked about paternal exposures, and briefly review what is known about the risk of paternal exposure to the 10 agents which are most frequently queried.

摘要

与母亲接触致畸物相比，父亲接触致畸物对胎儿发育产生不良影响的可能性很少受到关注。然而，人们越来越担心接触致畸剂会导致男性介导的发育毒性。致畸物信息服务机构接到的关于父亲接触致畸物的咨询电话数量就证明了这一点。在本文中，我们报告了佛罗里达州致畸物信息服务机构在处理有关父亲接触致畸物问题方面的经验，并简要回顾一下目前已知的关于父亲接触最常被咨询的10种致畸物的风险情况。