Hermann M, Scholman H J, Marafioti T, Stein H, Schriever F
Department of Hematology and Oncology, Virchow University Hospital, Humboldt University Berlin, Germany.
Eur J Haematol. 1997 Jul;59(1):20-30. doi: 10.1111/j.1600-0609.1997.tb00955.x.
Bcl-x and c-Myc have an important role for the immune response by regulating the programmed cell death (apoptosis) of lymphocytes. Dysfunction of these selection processes can lead to the development of malignant lymphoma. The present study aimed at defining the differential expression of apoptosis, Bcl-x and c-Myc in normal and in malignant lymphoid tissues. Follicular centre lymphoma (FCL-F) and mantle cell lymphoma (MCL) contained the lowest apoptotic indices (AIs), whereas Burkitt's lymphoma (BL) had the highest AIs. The AIs correlated significantly with the growth rates of the tumours and with the extent of Bcl-x expression. Bcl-x was expressed in almost all BL cells, but in few tumour cells in FCL-F and in MCL. c-Myc, in contrast, was found in the majority of the tumour cells in FCL-F and in MCL, but not in BL. Whereas the extent of Bcl-x expression correlated positively with the growth rates, an inverse correlation was observed between the percentages of c-Myc-positive tumour cells and the growth rates of the tumours. We conclude that normal and malignant lymphoid tissues have a distinct pattern of apoptosis and that expression of Bcl-x and c-Myc in B cell lymphoma is differentially regulated.
Bcl-x和c-Myc通过调节淋巴细胞的程序性细胞死亡（凋亡）在免疫反应中发挥重要作用。这些选择过程的功能障碍可导致恶性淋巴瘤的发生。本研究旨在确定正常和恶性淋巴组织中凋亡、Bcl-x和c-Myc的差异表达。滤泡中心淋巴瘤（FCL-F）和套细胞淋巴瘤（MCL）的凋亡指数（AI）最低，而伯基特淋巴瘤（BL）的AI最高。AI与肿瘤的生长速率以及Bcl-x的表达程度显著相关。Bcl-x在几乎所有BL细胞中表达，但在FCL-F和MCL的少数肿瘤细胞中表达。相比之下，c-Myc在FCL-F和MCL的大多数肿瘤细胞中发现，但在BL中未发现。虽然Bcl-x的表达程度与生长速率呈正相关，但c-Myc阳性肿瘤细胞的百分比与肿瘤的生长速率之间呈负相关。我们得出结论，正常和恶性淋巴组织具有不同的凋亡模式，并且B细胞淋巴瘤中Bcl-x和c-Myc的表达受到不同的调节。
