Boyano M D, García-Vázquez M D, Gardeazabal J, García de Galdeano A, Smith-Zubiaga I, Cañavate M L, Raton J A, Bilbao I, Díaz-Pérez J L
Department of Cell Biology and Morphological Sciences, School of Medicine and Dentistry, University of the Basque Country, Leioa, Spain.
Oncology. 1997 Sep-Oct;54(5):400-6. doi: 10.1159/000227726.
Elevated soluble IL-2 receptor (sIL-2R) and IL-6 serum concentrations have been reported as adverse prognostic factors in several types of cancer. In order to determine whether these factors are predictive of metastatic progression in melanoma, sIL-2R and IL-6 levels were measured in sera from 172 patients with melanoma and 60 in healthy controls. Mean sIL-2R values were significantly higher in the patients than in normal controls and the highest values were observed in those that developed metastasis during follow-up. However, no correlation was found with the stage of the disease. Serum IL-6 levels were found to be correlated with age and sex, but not correlated with sIL-2R levels. Statistical analysis was based on logistic and Cox regression models. The factors considered were age, sex, stage, disease-free interval and serum sIL-2R and IL-6 levels. The analysis showed that only the sIL-2R value is significantly linked to metastatic progression. This finding suggests that high serum levels of sIL-2R could be a predictive factor of metastatic progression in malignant melanoma.
可溶性白细胞介素-2受体（sIL-2R）和白细胞介素-6血清浓度升高已被报道为几种癌症的不良预后因素。为了确定这些因素是否可预测黑色素瘤的转移进展，我们检测了172例黑色素瘤患者和60例健康对照者血清中的sIL-2R和白细胞介素-6水平。患者的平均sIL-2R值显著高于正常对照者，且在随访期间发生转移的患者中观察到最高值。然而，未发现其与疾病分期相关。血清白细胞介素-6水平与年龄和性别相关，但与sIL-2R水平无关。统计分析基于逻辑回归和Cox回归模型。所考虑的因素包括年龄、性别、分期、无病间期以及血清sIL-2R和白细胞介素-6水平。分析表明，只有sIL-2R值与转移进展显著相关。这一发现提示，血清sIL-2R水平升高可能是恶性黑色素瘤转移进展的一个预测因素。
