Tzingounis V, Katsilambros N, Prevedourakis C, Papaevangelou G
J Reprod Med. 1977 Nov;19(5):259-61.
The effects of excessive maternal weight gain during pregnancy (five cases) and of glucose infusion in the mother (five cases) on insulin levels are compared with the insulin levels in a control group (19 normal pregnancies) by radioimmunologic determination of insulin levels in the amniotic fluid and in maternal and fetal blood. The mean values for insulin in the control group were as follows: mother, 23.9 +/- 2.23 muU per ml; fetus, 9.86 +/- 2.11 muU per ml; and amniotic fluid, 5.08 +/- 2.27 muU per ml. In patients with excessive weight gain during pregnancy, maternal insulin mean values were 38.45 +/- 4.16 muU per ml; fetal, 19.99 +/- 9.8 muU per ml; and amniotic fluid, 11.25 +/- 2.58 muU per ml. After an infusion of 25 mg of glucose in the mother, the mean maternal insulin values were 53.6 +/- 13.74 muU per ml; fetal, 24.7 +/- 6.67 muU per ml; and amniotic fluid, 14.3 +/- 5.52 muU per ml. Insulin concentrations in maternal blood (p less than 0.001), fetal blood (p less than 0.001) and amniotic fluid (p less than 0.001) were higher in pregnancies with excessive weight gain as compared to those in the control group, whereas the glucose infusion in the mother increased the concentration of insulin in the three components studied.
通过放射免疫法测定羊水、母体血液和胎儿血液中的胰岛素水平，将孕期母亲体重过度增加（5例）和母亲输注葡萄糖（5例）对胰岛素水平的影响与对照组（19例正常妊娠）的胰岛素水平进行比较。对照组胰岛素的平均值如下：母亲，每毫升23.9±2.23微单位；胎儿，每毫升9.86±2.11微单位；羊水，每毫升5.08±2.27微单位。在孕期体重过度增加的患者中，母体胰岛素平均值为每毫升38.45±4.16微单位；胎儿为每毫升19.99±9.8微单位；羊水为每毫升11.25±2.58微单位。母亲输注25毫克葡萄糖后，母体胰岛素平均值为每毫升53.6±13.74微单位；胎儿为每毫升24.7±6.67微单位；羊水为每毫升14.3±5.52微单位。与对照组相比，孕期体重过度增加的孕妇母体血液（p<0.001）、胎儿血液（p<0.001）和羊水（p<0.001）中的胰岛素浓度更高，而母亲输注葡萄糖会增加所研究的三个成分中的胰岛素浓度。
