Kadota-Shinozaki A, Nakamura T, Hidaka H, Kojima H, Yasuda H, Kashiwagi A, Kikkawa R
Third Department of Medicine, Shiga University of Medical Science, Ohtsu.
Intern Med. 1997 Aug;36(8):571-4. doi: 10.2169/internalmedicine.36.571.
A 19-year-old woman with diabetic lipemia and maturity-onset diabetes of the young (MODY) is reported. Though her insulin secretory activity was preserved, she fell into mild diabetic ketoacidosis (DKA) and showed type V hyperlipidemia. Post-heparin plasma activity of lipoprotein lipase (LPL) was decreased even 10 days after initiating insulin injection but not deficient. The abnormalities in lipid metabolism were improved by long-term insulin treatment. Though the contribution of the genetic background to the lipid abnormalities is not clear, the characteristics of MODY in this patient including insulin secretory capacity under stress conditions such as DKA might play a role in the development of diabetic lipemia.
报告了一名19岁患有糖尿病性脂血症和青年发病的成年型糖尿病（MODY）的女性。尽管她的胰岛素分泌活性得以保留，但她仍陷入轻度糖尿病酮症酸中毒（DKA）并表现出V型高脂血症。即使在开始注射胰岛素10天后，脂蛋白脂肪酶（LPL）的肝素后血浆活性仍降低，但并非缺乏。长期胰岛素治疗改善了脂质代谢异常。尽管遗传背景对脂质异常的影响尚不清楚，但该患者MODY的特征，包括在DKA等应激条件下的胰岛素分泌能力，可能在糖尿病性脂血症的发生中起作用。
