Knepper M A, Inoue T
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-0951, USA.
Curr Opin Cell Biol. 1997 Aug;9(4):560-4. doi: 10.1016/s0955-0674(97)80034-8.
Vasopressin regulates water excretion from the kidney by increasing the osmotic water permeability of the renal collecting duct. The aquaporin-2 water channel has been demonstrated to be the target for this action of vasopressin. Recent studies have demonstrated that vasopressin, acting through cyclic AMP, triggers fusion of aquaporin-2-bearing vesicles with the apical plasma membrane of the collecting duct principal cells. The vesicle-targeting proteins synaptobrevin-2 and syntaxin-4 are proposed to play roles in this process.
血管加压素通过增加肾集合管的渗透水通透性来调节肾脏的水排泄。水通道蛋白-2水通道已被证明是血管加压素这一作用的靶点。最近的研究表明，血管加压素通过环磷酸腺苷发挥作用，触发含水通道蛋白-2的囊泡与集合管主细胞顶端质膜融合。囊泡靶向蛋白突触结合蛋白-2和 syntaxin-4 被认为在这一过程中发挥作用。
