Barrows G H, Christopherson W M, Drill V A
J Toxicol Environ Health. 1977 Sep;3(1-2):219-30. doi: 10.1080/15287397709529561.
Two strains of mice, CF-LP and Swiss-Webster random-bred, were evaluated for liver neoplasia after administration of oral contraceptive steroids. No increased incidence of hepatocellular tumors was found beyond the variation expected by chance. The overall tumor incidence in treated and untreated groups was identical. No significant increase in tumor size was observed in the treated animals. Liver weights progressively increased in several of the treated groups. In both treated and untreated animals hepatocellular neoplasia was usually accompanied by intracytoplasmic inclusions similar to those observed in human liver tumors. Vascular lesions were observed in some of the animals receiving large doses of contraceptive steroids. While these may be the result of local toxicity, their similarity to lesions observed in benign liver tumors warrants further investigation. No evidence was found to suggest that contraceptive steroids act as initiators of liver neoplasia.
对两种品系的小鼠，即CF-LP和瑞士韦伯斯特随机繁殖小鼠，在给予口服避孕类固醇后进行了肝肿瘤形成评估。未发现肝细胞肿瘤的发生率有超出偶然预期变异的增加。治疗组和未治疗组的总体肿瘤发生率相同。在接受治疗的动物中未观察到肿瘤大小有显著增加。几个治疗组的肝脏重量逐渐增加。在治疗和未治疗的动物中，肝细胞肿瘤通常伴有与人类肝脏肿瘤中观察到的相似的胞质内包涵体。在一些接受大剂量避孕类固醇的动物中观察到血管病变。虽然这些可能是局部毒性的结果，但它们与良性肝肿瘤中观察到的病变相似性值得进一步研究。没有发现证据表明避孕类固醇是肝肿瘤形成的启动剂。
