Beck F X, Thurau K
Department of Physiology, University of Munich, Federal Republic of Germany.
Wien Klin Wochenschr. 1997 Jun 27;109(12-13):424-8.
Rubidium (Rb) was used as a marker ion for K to assess Na/K(Rb)-ATPase activity in single renal tubule cells. Initial Rb uptake rates were measured by electron microprobe analysis in individual tubule cells of the rat kidney during acute stimulation or during inhibition of transepithelial Na absorption. Under these conditions, Rb uptake closely correlates with intracellular Na concentrations, indicating that the intracellular Na concentration is a major determinant in the precise adjustment of basolateral, Na/K(Rb)-ATPase-dependent Na extrusion to Na entry across the apical cell membrane. Chronically increased distal Na delivery induced by loop diuretics triggers adaptive processes which allow increased transcellular Na movement at normal or near-normal intracellular Na concentrations.
铷（Rb）被用作钾的标记离子，以评估单个肾小管细胞中的钠/钾（铷）-ATP酶活性。在急性刺激或抑制跨上皮钠吸收期间，通过电子微探针分析测量大鼠肾脏单个肾小管细胞中的初始铷摄取率。在这些条件下，铷摄取与细胞内钠浓度密切相关，表明细胞内钠浓度是精确调节基底外侧钠/钾（铷）-ATP酶依赖性钠排出与通过顶端细胞膜进入的钠的主要决定因素。袢利尿剂引起的慢性增加的远端钠输送触发适应性过程，该过程允许在正常或接近正常的细胞内钠浓度下增加跨细胞钠运动。
