Carr M M, Thorner P, Phillips J H
Department of Otolaryngology, Dalbousie University, Halifax.
J Otolaryngol. 1997 Aug;26(4):246-52.
This article reviews teratomas, neoplasms composed of the three germinal layers of the embryo that form tissues foreign to the part in which they arise. These are most common in the sacrococcygeal region and are rare in the head and neck. In this region, major concerns are airway obstruction and cosmesis.
Pathology records at two tertiary care paediatric hospitals were reviewed for diagnoses of head and neck teratomas. This revealed nine cases between 1983 and 1993, five males and four females. Two males were stillborn. Five were cervical, two were in the nasopharynx, and two were facial. The lesions were immature in two cases and mature in the remainder. All of the liveborn children underwent surgery within the first year of life, and only one required tracheotomy.
One child had recurrence of teratomatous tissue diagnosed with CT, which was treated surgically. The child has remained free of tumour for over 3 years. Pathogenesis, clinical appearance, diagnostic work-up, and currently accepted modes of therapy are reviewed.
本文综述畸胎瘤,它是由胚胎的三个胚层组成的肿瘤,能形成与其起源部位不同的组织。这些肿瘤在骶尾部最为常见,在头颈部则较为罕见。在该区域,主要问题是气道阻塞和美容。
回顾了两家三级儿科医院的病理记录,以诊断头颈部畸胎瘤。结果发现1983年至1993年间有9例病例,5例男性,4例女性。2例男性为死产。5例位于颈部,2例位于鼻咽部,2例位于面部。2例病变为未成熟型,其余为成熟型。所有存活的儿童在出生后第一年内均接受了手术,只有1例需要气管切开术。
1名儿童经CT诊断畸胎瘤组织复发,接受了手术治疗。该儿童已无肿瘤超过3年。本文还综述了发病机制、临床表现、诊断检查以及目前公认的治疗方式。