Wala E P, Sloan J W, Jing X
Department of Anesthesiology, College of Medicine, University of Kentucky, Lexington 40536-0216, USA.
Pharmacol Biochem Behav. 1997 Sep;58(1):221-9. doi: 10.1016/s0091-3057(97)00013-0.
Flumazenil (FLU; 25 micrograms) and DMSO-vehicle were focally injected (1 microliter) into the substantia nigra (SN) and the dorsal raphe nucleus (DR) in rats chronically implanted with silastic capsules containing diazepam (DZ; 540 mg/week). FLU precipitated an abstinence syndrome in the SN as indicated by a significant abstinence score, several abstinence signs and reduced total power of the fast frequency bands of the electroencephalogram (EEG) in the injections sites frontal cortex, (FC) and hippocampus (H). In contrast, FLU did not produce an abstinence syndrome in the DR, and its effect on the power of the EEG in DR, FC and H was not significantly different from that of the DMSO-vehicle. The data show regional heterogeneity in the response of the SN and the DR to chronic DZ treatment in terms of a focally precipitated abstinence syndrome.
将氟马西尼（FLU；25微克）和二甲基亚砜溶媒（1微升）局部注射到长期植入含地西泮（DZ；540毫克/周）硅橡胶胶囊的大鼠的黑质（SN）和中缝背核（DR）中。如通过显著的戒断评分、多种戒断体征以及注射部位额叶皮质（FC）和海马体（H）脑电图（EEG）快频段总功率降低所表明的，FLU在SN中引发了戒断综合征。相比之下，FLU在DR中未产生戒断综合征，并且其对DR、FC和H中EEG功率的影响与二甲基亚砜溶媒的影响无显著差异。数据表明，就局部引发的戒断综合征而言，SN和DR对慢性DZ治疗的反应存在区域异质性。
