Svec F, Shawar A L
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112, USA.
Psychoneuroendocrinology. 1997;22 Suppl 1:S115-9. doi: 10.1016/s0306-4530(97)00022-x.
Lean [n = 11, body mass index (BMI) < 22.5] and obese (n = 13, BMI > 31.5) women consumed a noontime meal while serum levels of cortisol and dehydroepiandrosterone (DHEA) were measured. Before the meal the obese had lower levels of serum cortisol compared to the leans. Within 20-40 min of consuming the meal the levels of cortisol rose in both groups; those of the obese rose by a greater increment and in the first postprandial hour there were no differences between lean and obese. After the meal-induced peak, the obese again had lower cortisol values. DHEA levels rose with the meal in both groups but the difference over baseline was only significant for the obese. These results show that the lean and obese respond differently to the physiologic stimulus of a meal. These results are consistent with the hypothesis that obesity is influenced by differences in adrenal function that are demonstrable during stimulation with a meal.
消瘦女性（n = 11，体重指数（BMI）< 22.5）和肥胖女性（n = 13，BMI > 31.5）进食午餐时，测量其血清皮质醇和脱氢表雄酮（DHEA）水平。用餐前，肥胖女性的血清皮质醇水平低于消瘦女性。用餐后20 - 40分钟内，两组的皮质醇水平均升高；肥胖女性升高幅度更大，且在餐后第一小时，消瘦和肥胖女性之间无差异。餐后峰值过后，肥胖女性的皮质醇值再次降低。两组的DHEA水平均随用餐升高，但仅肥胖女性超过基线的差异具有统计学意义。这些结果表明，消瘦和肥胖女性对用餐的生理刺激反应不同。这些结果与以下假设一致，即肥胖受用餐刺激时可表现出的肾上腺功能差异影响。
