Holsten F, Bjorvatn B
Psykiatrisk institutt, Universitet i Bergen, Haukeland Sykehus.
Tidsskr Nor Laegeforen. 1997 Jun 30;117(17):2484-8.
Although clinicians have observed for centuries that som depressed patients become worse in the winter, it was first in 1984 that Norman Rosenthal and co-workers described a syndrome which they called seasonal affective disorder (SAD), characterised by winter depression, lethargy and a craving for carbohydrate. Phototherapy was proved to be an effective treatment right from the start. Recently it has been reported that not only depression, but also panic disorder and obsessive compulsive disorders may exhibit a seasonal pattern and thus benefit from phototherapy. Phototherapy may also benefit patients suffering from "sun-downing", a syndrome of confusion and agitation in the evening in persons with Alzheimer's disease. Based on the observation that bright light may both elevate brain serotonin and ameliorate sleep abnormalities, the authors report the results of phototherapy for treatment of non-seasonal depressions, either alone or in combination with antidepressants or sleep deprivation.
尽管几个世纪以来临床医生都观察到一些抑郁症患者在冬季病情会加重,但直到1984年诺曼·罗森塔尔及其同事才描述了一种他们称之为季节性情感障碍(SAD)的综合征,其特征为冬季抑郁、嗜睡和对碳水化合物的渴望。从一开始,光疗法就被证明是一种有效的治疗方法。最近有报道称,不仅抑郁症,恐慌症和强迫症也可能呈现季节性模式,因此可从光疗法中受益。光疗法可能对患有“日落综合征”的患者也有益,“日落综合征”是阿尔茨海默病患者在傍晚出现的一种混乱和激动的综合征。基于强光可能会提高大脑血清素水平并改善睡眠异常这一观察结果,作者报告了光疗法单独或与抗抑郁药或睡眠剥夺联合治疗非季节性抑郁症的结果。