Tamminga C A, Conley R R
Maryland Psychiatric Research Center, University of Maryland Medical School, Baltimore 21228, USA.
J Clin Psychiatry. 1997;58 Suppl 10:3-6.
Neuroimaging is a powerful and innovative tool for studying the pathology of psychiatric diseases and, more recently, for studying the drugs used in their treatment. Technological advances in imaging have made it possible to noninvasively extract information from the human brain regarding a drug's mechanism and site of action. Until now, our understanding of human brain pharmacology has depended primarily on indirect assessments or models derived from animal studies. However, the advent of multiple techniques for human brain imaging allows researchers to focus directly on human pharmacology and brain function. This review outlines available neuroimaging techniques and examines how these various methods have already been applied to the drug development process, as well as how they might be applied in the future.
神经影像学是研究精神疾病病理学的一种强大且创新的工具，最近也用于研究治疗精神疾病的药物。成像技术的进步使得从人脑非侵入性地提取有关药物作用机制和作用部位的信息成为可能。到目前为止，我们对人脑药理学的理解主要依赖于间接评估或从动物研究得出的模型。然而，多种人脑成像技术的出现使研究人员能够直接关注人类药理学和脑功能。本综述概述了现有的神经影像学技术，并探讨了这些不同方法如何已应用于药物研发过程，以及它们未来可能如何应用。
