临床多巴胺成像的应用。

Applications of clinical dopamine imaging.

作者信息

Lindsey Kimberly P, Gatley S John

机构信息

Department of Psychiatry, Harvard University Medical School, 115 Mill Street, Belmont, MA 02478, USA.

出版信息

Neuroimaging Clin N Am. 2006 Nov;16(4):553-73, vii-viii. doi: 10.1016/j.nic.2006.06.003.

DOI:10.1016/j.nic.2006.06.003

PMID:17148019

Abstract

Recent technologic advances make it increasingly possible to image neurotransmitter systems in living human brain, The dopamine system has been most intensively studied owing to its involvement in several brain disorders such as Parkinson's disease and Huntington's disease, as well as psychiatric disorders such as schizophrenia, depression, and compulsive behavioral disorders of multiple types. A variety of aspects of dopamine receptor density, function, and dopaminergic terminal status can now be assessed using the minimally invasive neuroimaging techniques of positron emission tomography and single-photon emission computed tomography. Although these techniques are currently used most often in the context of research, clinical applications are rapidly emerging.

摘要

最近的技术进步使得在活体人类大脑中对神经递质系统进行成像变得越来越可行。由于多巴胺系统涉及多种脑部疾病，如帕金森病和亨廷顿病，以及精神疾病，如精神分裂症、抑郁症和多种类型的强迫行为障碍，因此对其研究最为深入。现在可以使用正电子发射断层扫描和单光子发射计算机断层扫描等微创神经成像技术来评估多巴胺受体密度、功能和多巴胺能终末状态的各个方面。虽然这些技术目前最常用于研究背景下，但临床应用正在迅速兴起。