白塞病中血清白细胞介素-8和超氧化物歧化酶的检测

The demonstration of serum interleukin-8 and superoxide dismutase in Adamantiades-Behçet's disease.

作者信息

Wang L M, Kitteringham N, Mineshita S, Wang J Z, Nomura Y, Koike Y, Miyashita E

机构信息

Department of Preventive Medicine, Tokyo Medical and Dental University, Japan.

出版信息

Arch Dermatol Res. 1997 Jul;289(8):444-7. doi: 10.1007/s004030050219.

DOI:10.1007/s004030050219

PMID:9266021

Abstract

Serum interleukin-8 (IL-8) production was measured in 43 Adamantiades-Behçet's disease (A-BD) patients and in 46 healthy volunteers using a sandwich enzyme-linked immunosorbent assay (ELISA). The mean serum IL-8 level of the patients (14.6 +/- 3 pg/ml) was significantly higher than that of controls (10.8 +/- 3 pg/ml, P < 0.05). Since IL-8 is known to have proinflammatory properties, it may play some role in the pathogenesis of A-BD. We also investigated the activity of serum superoxide dismutase (SOD) in the 43 patients with A-BD and in the 46 healthy volunteers. Serum SOD activity was markedly increased in the patients with A-BD (13.1 +/- 3%), especially in active A-BD, compared with that in the healthy volunteers (6.7 +/- 3%, P < 0.01). Our results suggest the involvement of IL-8 and SOD in the pathogenesis of A-BD as seen in other inflammatory diseases.

摘要

采用夹心酶联免疫吸附测定法（ELISA），对43例白塞病（A-BD）患者和46名健康志愿者的血清白细胞介素-8（IL-8）生成情况进行了检测。患者的血清IL-8平均水平（14.6±3 pg/ml）显著高于对照组（10.8±3 pg/ml，P<0.05）。由于已知IL-8具有促炎特性，其可能在A-BD的发病机制中发挥一定作用。我们还对43例A-BD患者和46名健康志愿者的血清超氧化物歧化酶（SOD）活性进行了研究。与健康志愿者相比，A-BD患者的血清SOD活性显著升高（13.1±3%），尤其是在活动期A-BD患者中（6.7±3%，P<0.01）。我们的结果表明，与其他炎症性疾病一样，IL-8和SOD参与了A-BD的发病机制。