Fawzy Rasha M, Said Emtethal A, Mohamed Soha M, Fouad Nehad A, Akl Essam M
Department of Rheumatology and Rehabilitation, Faculty of Medicine, Benha University, Benha, Egypt.
Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Egypt.
Egypt J Immunol. 2015 Jun;22(2):1-8.
Behcet's disease (BD) is a chronic systemic inflammatory disorder characterized by a course of remissions and exacerbations of unpredictable frequency and duration. Pro-inflammatory cytokines seem to be responsible for the enhanced inflammatory response in BD.
This study aimed to investigate serum levels of IL-33 in patients with Behcet's disease (BD) and their relationship to disease activity and clinical manifestations. Thirty patients with BD were enrolled and subjected to assessment of disease activity according to Behcet's Disease Current Activity Form (BDCAF) score. Serum IL-33 levels were determined using Enzyme-Linked-Immunosorbent Assay (ELISA). Thirty age and sex matched rheumatoid arthritis patients and thirty healthy volunteers were included in this study as control groups. Serum IL-33 level was 132.5±19 pg\ml, 101.2±20.1 pg\ml and 31.5±10.5 pg\ml in RA, BD and healthy control groups respectively. IL-33 was significantly higher in BD patients (101.2±20.1pg/ml) as compared to healthy controls (31.5±10.5 pg/ml) but lower than rheumatoid arthritis patients (132.5±19.1 pg/ml). Levels of IL-33 were significantly increased in BD patients with skin lesions (Erythema nodosum & Acneiform lesions) and ocular lesions (retinal vasculitis) (P<0.05), and a positive correlation was found between BDCAF score and IL-33serum levels (r=0.9, P<0.001). In conclusions, serum IL-33 level is elevated in active BD patients with skin and ocular affection and correlates with disease activity.
白塞病（BD）是一种慢性全身性炎症性疾病，其特点是缓解期和加重期的病程频率和持续时间不可预测。促炎细胞因子似乎是导致白塞病炎症反应增强的原因。
本研究旨在调查白塞病（BD）患者血清白细胞介素-33（IL-33）水平及其与疾病活动度和临床表现的关系。纳入30例BD患者，并根据白塞病当前活动度表（BDCAF）评分评估疾病活动度。采用酶联免疫吸附测定（ELISA）法测定血清IL-33水平。本研究纳入30例年龄和性别匹配的类风湿关节炎患者和30例健康志愿者作为对照组。类风湿关节炎组、白塞病组和健康对照组的血清IL-33水平分别为132.5±19 pg/ml、101.2±20.1 pg/ml和31.5±10.5 pg/ml。与健康对照组（31.5±10.5 pg/ml）相比，白塞病患者的IL-33水平显著升高（101.2±20.1 pg/ml），但低于类风湿关节炎患者（132.5±19.1 pg/ml）。有皮肤病变（结节性红斑和痤疮样皮损）和眼部病变（视网膜血管炎）的白塞病患者IL-33水平显著升高（P<0.05），且BDCAF评分与血清IL-33水平呈正相关（r=0.9，P<0.001）。结论：有皮肤和眼部受累的活动性白塞病患者血清IL-33水平升高，且与疾病活动度相关。
