Harbuz M S, Chover-Gonzalez A J, Conde G L, Renshaw D, Lightman S L, Jessop D S
University Department of Medicine, Bristol Royal Infirmary, UK.
Neuroimmunomodulation. 1996 Nov-Dec;3(6):358-63. doi: 10.1159/000097296.
The effects of cytokines in stimulating neurohypophysial hormone release have not been well characterized. In the present study, we have investigated the effect of intraperitoneal injection of recombinant human interleukin (IL)-1 beta on oxytocin release in sham-operated controls, adrenalectomized (ADX) rats and ADX rats given either low or high doses of the synthesis glucocorticoid dexamethasone. In a second study, we determined the effect of central injection of IL-1 beta on both oxytocin and arginine vasopressin (AVP) release in sham-operated and ADX rats. We were unable to demonstrate an increase in plasma oxytocin in intact rats in response to intraperitoneal injection of IL-1 beta. In contrast, we found a substantial and sustained increase in plasma oxytocin concentrations in ADX rats. This stimulation was abolished by treatment with dexamethasone at both the low and high doses. Following central injection of IL-1 beta, we were unable to demonstrate any increase in either oxytocin or AVP, despite the ability of this dose of cytokine to stimulate the hypothalamo-pituitary-adrenal axis, as evidenced by increased circulating corticosterone. It appears that circulating glucocorticoids may exert a tonic inhibitory effect on the release of oxytocin in response to peripheral stimulation by IL-1 beta.
细胞因子在刺激神经垂体激素释放方面的作用尚未得到充分阐明。在本研究中，我们研究了腹腔注射重组人白细胞介素（IL）-1β对假手术对照组、肾上腺切除（ADX）大鼠以及给予低剂量或高剂量合成糖皮质激素地塞米松的ADX大鼠中催产素释放的影响。在第二项研究中，我们测定了向假手术和ADX大鼠中枢注射IL-1β对催产素和精氨酸加压素（AVP）释放的影响。我们未能证明完整大鼠腹腔注射IL-1β后血浆催产素增加。相反，我们发现ADX大鼠血浆催产素浓度有显著且持续的升高。低剂量和高剂量地塞米松治疗均可消除这种刺激。向中枢注射IL-1β后，尽管该剂量的细胞因子能够刺激下丘脑-垂体-肾上腺轴，循环皮质酮增加可证明这一点，但我们未能证明催产素或AVP有任何增加。似乎循环糖皮质激素可能对IL-1β外周刺激引起的催产素释放产生紧张性抑制作用。
