Shults C W, Haas R H, Passov D, Beal M F
Neurology Service, Veterans Affairs Medical Center, San Diego, CA 92161, USA.
Ann Neurol. 1997 Aug;42(2):261-4. doi: 10.1002/ana.410420221.
The activities of complex I and complex II/III in platelet mitochondria are reduced in patients with early, untreated Parkinson's disease. Coenzyme Q10 is the electron acceptor for complex I and complex II. We found that the level of coenzyme Q10 was significantly lower in mitochondria from parkinsonian patients than in mitochondria from age- and sex-matched control subjects and that the levels of coenzyme Q10 and the activities of complex I and complex II/III were significantly correlated.
早期未经治疗的帕金森病患者血小板线粒体中复合物I以及复合物II/III的活性降低。辅酶Q10是复合物I和复合物II的电子受体。我们发现，帕金森病患者线粒体中辅酶Q10的水平显著低于年龄和性别匹配的对照受试者线粒体中的水平，并且辅酶Q10水平与复合物I和复合物II/III的活性显著相关。
