Adachi I, Hou N, Komori T, Tabuchi K, Matsui R, Sueyoshi K, Narabayashi I, Matsuda S, Tamoto S
Department of Radiology, Osaka Medical College.
Kaku Igaku. 1997 Jun;34(6):363-9.
Dipyridamole-loading 99mTc-tetrofosmin myocardial scintigraphy was performed for patients with coronary artery disease who underwent percutaneous transluminal coronary angioplasty (PTCA) in order to examine whether SPECT imaging prior to treatment is useful for the determination of prognosis after coronary intervention. Thirty-six patients including 9 with angina pectoris (AP), 22 with old myocardial infarction (OMI) and 5 OMI with AP were underwent dipyridamole-loading 99mTc-tetrofosmin myocardial SPECT before and after coronary intervention. The length of follow-up was 185 +/- 107 days after PTCA. Improvement of myocardial uptake was observed on myocardial SPECT in all cases with AP. Improvement of the myocardial uptake was observed 50% (4/8) of patients with OMI who had no myocardial viability. It was suggested that the improvement of myocardial uptake after PTCA was due to incomplete fill-in in cases with AP and that the presence of fill-in was important for level of fill-in in patients with AP. The improvement of myocardial uptake in the scar tissue in patients with OMI contributed to the hibernating myocardium. We concluded that correct detection of hibernating myocardium was difficult despite the superior imaging capability of 99mTc-tetrofosmin myocardial SPECT.
对接受经皮腔内冠状动脉成形术（PTCA）的冠心病患者进行双嘧达莫负荷99mTc-替曲膦心肌闪烁显像，以检查治疗前的单光子发射计算机断层扫描（SPECT）成像是否有助于确定冠状动脉介入治疗后的预后。36例患者，包括9例心绞痛（AP）患者、22例陈旧性心肌梗死（OMI）患者和5例合并AP的OMI患者，在冠状动脉介入治疗前后接受了双嘧达莫负荷99mTc-替曲膦心肌SPECT检查。PTCA术后随访时间为185±107天。所有AP患者的心肌SPECT均观察到心肌摄取改善。在无心肌存活的OMI患者中，50%（4/8）观察到心肌摄取改善。提示PTCA后AP患者心肌摄取改善是由于充盈不完全，而AP患者充盈的存在对充盈水平很重要。OMI患者瘢痕组织中心肌摄取的改善有助于冬眠心肌。我们得出结论，尽管99mTc-替曲膦心肌SPECT具有卓越的成像能力，但正确检测冬眠心肌仍很困难。
