Wong T Y, Chan C, Lim L, Lim T H, Tan D T
Singapore National Eye Center, Singapore.
Aust N Z J Ophthalmol. 1997 May;25(2):145-50. doi: 10.1111/j.1442-9071.1997.tb01296.x.
To study the changing indications for penetrating keratoplasty in Singapore and compare local indications with developed countries with established corneal graft programs.
A descriptive study of all penetrating keratoplasty cases performed in the Singapore National Eye Center over a 5 year period, from 1 January 1991 to 31 December 1995 using records of the Singapore Eye Bank registry.
A total of 327 penetrating keratoplasties were performed. Bullous keratopathy was the indication in more than a quarter of all cases (26.3%). Aphakic bullous keratopathy (11.6%) and pseudophakic bullous keratopathy (11.3%) accounted for the majority of the bullous keratopathy cases. The other leading indications were regrafts (11.9%), corneal dystrophies (10.4%), traumatic scarring (10.1%) and keratoconus (9.8%). A higher proportion of aphakic and pseudophakic bullous keratopathy as well as regrafts was noted in this series compared to a previous report on corneal transplantation in the 1980s. A rising indication rate of pseudophakic bullous keratopathy, in conjunction with a declining indication rate of herpetic keratitis was observed over the 5 year study period.
The indications for penetrating keratoplasty in Singapore appear to follow the trend seen in developed Western countries over the past few decades.
研究新加坡穿透性角膜移植术适应症的变化情况，并将本地适应症与已开展角膜移植项目的发达国家进行比较。
采用新加坡眼库登记记录，对1991年1月1日至1995年12月31日这5年期间在新加坡国立眼科中心进行的所有穿透性角膜移植病例进行描述性研究。
共进行了327例穿透性角膜移植术。大泡性角膜病变是超过四分之一病例（26.3%）的适应症。无晶状体大泡性角膜病变（11.6%）和人工晶状体大泡性角膜病变（11.3%）占大泡性角膜病变病例的大多数。其他主要适应症为再次移植（11.9%）、角膜营养不良（10.4%）、创伤性瘢痕形成（10.1%）和圆锥角膜（9.8%）。与20世纪80年代关于角膜移植的先前报告相比，本系列中无晶状体和人工晶状体大泡性角膜病变以及再次移植的比例更高。在5年的研究期间，观察到人工晶状体大泡性角膜病变的适应症发生率上升，同时疱疹性角膜炎的适应症发生率下降。
新加坡穿透性角膜移植术的适应症似乎遵循了过去几十年西方发达国家所见的趋势。
