Cursiefen C, Küchle M, Naumann G O
Department of Ophthalmology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Cornea. 1998 Sep;17(5):468-70. doi: 10.1097/00003226-199809000-00002.
To analyze recent trends in the indications for penetrating keratoplasty.
After keratoplasty, 2,557 corneal buttons were sent to and analyzed in the ophthalmopathology laboratory of the University of Erlangen-Nürnberg, Erlangen, Germany, between 1992 and 1996. Of these, 1,250 random corneal buttons were evaluated in this study.
Histopathologic diagnoses were (a) keratoconus (20.9%), (b) corneal scarring after keratitis/trauma (20.4%), (c) pseudophakic/aphakic bullous keratopathy (17%), (d) regraft (15.5%), (e) Fuchs' corneal endothelial dystrophy (14.9%), (f) necrotizing/ulcerative keratitis (5.3%), and (g) corneal dystrophies (1.7%).
Compared with a previous report from our laboratory (1964-1986), the relative frequencies of pseudophakic/aphakic bullous keratopathy, regraft, and Fuchs' dystrophy increased, whereas corneal scarring decreased. Keratoconus is now the most frequent indication for penetrating keratoplasty.
分析穿透性角膜移植术适应证的近期趋势。
1992年至1996年间,2557个角膜植片被送至德国埃尔朗根 - 纽伦堡大学眼科病理实验室进行分析。本研究对其中1250个随机选取的角膜植片进行了评估。
组织病理学诊断结果为:(a)圆锥角膜(20.9%),(b)角膜炎/外伤后角膜瘢痕(20.4%),(c)人工晶状体眼/无晶状体眼大泡性角膜病变(17%),(d)再次移植(15.5%),(e)富克斯角膜内皮营养不良(14.9%),(f)坏死性/溃疡性角膜炎(5.3%),以及(g)角膜营养不良(1.7%)。
与我们实验室之前的一份报告(1964 - 1986年)相比,人工晶状体眼/无晶状体眼大泡性角膜病变、再次移植和富克斯营养不良的相对频率增加,而角膜瘢痕减少。圆锥角膜现在是穿透性角膜移植术最常见的适应证。