动物角膜移植术的结果：最新进展
Keratoprosthesis results in animals: an update.
作者信息
Hicks C R, Lou X, Platten S, Clayton A B, Vijayasekaran S, Fitton H J, Chirila T V, Crawford G J, Constable I J
机构信息
Lions Eye Institute, Nedlands, Australia.
出版信息
Aust N Z J Ophthalmol. 1997 May;25 Suppl 1:S50-2. doi: 10.1111/j.1442-9071.1997.tb01756.x.
BACKGROUND
The report presented is an update on continuing development work on modified PHEMA core-and-shirt KPros in animals.
METHODS
Two variations (improved wet-eye, and dry-eye) of a prototype core-and-skirt Chirila KPro are described. The clinical success rate on implantation of these versions of the Chirila KPro was assessed.
RESULTS
It was found that a significant improvement in retention rate was shown in the improved model but that the dry-eye model failed early in two of the three implanted.
CONCLUSIONS
The significance of the improved strength and the reasons for disappointing results with the early dry-eye KPros are discussed. Ongoing work is briefly outlined.
背景
所呈现的报告是关于改良型聚甲基丙烯酸羟乙酯（PHEMA）核-裙式人工角膜（KPro）在动物体内持续研发工作的最新进展。
方法
描述了Chirila核-裙式人工角膜原型的两种变体（改善泪眼和干眼）。评估了这些版本的Chirila人工角膜植入后的临床成功率。
结果
发现在改良模型中保持率有显著提高，但干眼模型在三只植入动物中有两只早期失败。
结论
讨论了改良强度的意义以及早期干眼人工角膜结果令人失望的原因。简要概述了正在进行的工作。
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