Chirila人工角膜在兔体内植入的临床结果。
Clinical results of implantation of the Chirila keratoprosthesis in rabbits.
作者信息
Hicks C R, Chirila T V, Clayton A B, Fitton J H, Vijayasekaran S, Dalton P D, Lou X, Platten S, Ziegelaar B, Hong Y, Crawford G J, Constable I J
机构信息
Lions Eye Institute, Perth, Western Australia.
出版信息
Br J Ophthalmol. 1998 Jan;82(1):18-25. doi: 10.1136/bjo.82.1.18.
AIMS/BACKGROUND: An ideal keratoprosthesis (KPro) would closely resemble a donor corneal button in terms of its surgical handling, optics, and capacity to heal with host tissue in order to avoid many of the complications associated with the KPros which are currently in clinical use. This study was carried out to assess the long term clinical outcomes on implantation of the core and skirt poly(2-hydroxyethyl methacrylate) KPro in animals.
METHODS
20 KPros were made and implanted as full thickness corneal replacements into rabbits and followed for up to 21 months to date.
RESULTS
80% of the prostheses have been retained, with a low incidence of complications such as cataract, glaucoma, and retroprosthetic membrane formation which are frequently associated with KPro surgery.
CONCLUSIONS
KPros of this type may offer promise in the treatment of patients for whom penetrating keratoplasty with donor material carries a poor prognosis. Refinement of the KPro and further animal trials, including implantation into abnormal corneas, are however mandatory before human implantation could be planned.
目的/背景：理想的人工角膜在手术操作、光学性能以及与宿主组织愈合的能力方面应与供体角膜片极为相似，以避免目前临床使用的人工角膜所引发的诸多并发症。本研究旨在评估核心及裙边聚甲基丙烯酸羟乙酯人工角膜植入动物后的长期临床效果。
方法
制作了20个该种人工角膜，并将其作为全层角膜替代物植入兔眼，至今已随访长达21个月。
结果
80%的假体得以保留，白内障、青光眼及人工角膜后膜形成等常与人工角膜手术相关的并发症发生率较低。
结论
此类人工角膜在治疗使用供体材料进行穿透性角膜移植预后不佳的患者方面可能具有前景。然而，在计划进行人体植入之前，必须对人工角膜进行改进并开展进一步的动物试验，包括植入异常角膜的试验。
Zotero 插件