鸡视网膜中的多巴胺能行为及形觉剥夺的影响。
Dopaminergic behaviour in chicken retina and the effect of form deprivation.
作者信息
Megaw P L, Morgan I G, Boelen M K
机构信息
Centre for Research on Ageing and Health, La Trobe University, Bendigo, Victoria, Australia.
出版信息
Aust N Z J Ophthalmol. 1997 May;25 Suppl 1:S76-8. doi: 10.1111/j.1442-9071.1997.tb01764.x.
PURPOSE
Dopamine (DA) is considered to be a neurotransmitter involved in light-adaptive responses in the retina and has been implicated in the control of the eye growth induced by form deprivation. Vitreal DOPAC was shown to be a good indicator of retinal dopaminergic activity.
METHODS/RESULTS: Dopaminergic activity was highest during the light; with vitreal DOPAC levels rising within 3 h of light exposure. Form deprivation attenuated dopaminergic activity, as the rise in vitreal DOPAC levels on light exposure was reduced in form-deprived eyes, compared with control eyes.
CONCLUSION
The lack of sustained activation of DA release may explain the role of DA in the control of eye-growth.
目的
多巴胺（DA）被认为是一种参与视网膜光适应反应的神经递质，并且与形态剥夺诱导的眼球生长控制有关。玻璃体内的3,4-二羟基苯乙酸（DOPAC）被证明是视网膜多巴胺能活性的良好指标。
方法/结果：多巴胺能活性在光照期间最高；玻璃体内DOPAC水平在光照3小时内升高。形态剥夺减弱了多巴胺能活性，因为与对照眼相比，形态剥夺眼在光照时玻璃体内DOPAC水平的升高有所降低。
结论
多巴胺释放缺乏持续激活可能解释了多巴胺在眼球生长控制中的作用。
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