Kohler S, Smoller B R
Department of Pathology, Stanford University Medical Center.
Dermatology. 1997;195(1):54-6. doi: 10.1159/000245688.
We present a case of extramammary Paget's disease (EMP) on the vulva of a 77-year-old female that on histologic examination resembled pemphigus vulgaris. The diagnosis of EMP was established with the help of a periodic acid-Schiff stain and immunophenotyping. Ultrastructural studies revealed no desmosomes between tumor cells and keratinocytes and only rare desmosomes between adjacent tumor cells. A high number of tumor cells with scant desmosomes may be the ultrastructural correlate with cellular discohesion in the lower epidermis and with the histologic resemblance to pemphigus vulgaris.
我们报告一例77岁女性外阴部的乳房外佩吉特病（EMP），其组织学检查结果类似寻常型天疱疮。借助过碘酸希夫染色和免疫表型分析确诊为EMP。超微结构研究显示肿瘤细胞与角质形成细胞之间无桥粒，相邻肿瘤细胞之间仅有罕见桥粒。大量桥粒稀少的肿瘤细胞可能是超微结构上与表皮下部细胞分离以及与组织学上类似寻常型天疱疮相关的表现。
