Griffiths K, Morton M S, Nicholson R I
Tenovus Cancer Research Centre, University of Wales College of Medicine, Cardiff, UK.
Eur Urol. 1997;32 Suppl 3:24-40.
Androgens play a major role in promoting the growth of the prostate gland. The DHT-androgen receptor complex, by association with the androgen response elements, specifically promotes this androgenic effect on the genome. Also recognized now, however, is that there is a close relationship between this androgen-mediated signalling pathway and those promoted by peptide growth factors, the crosstalk between the pathways being pivotal to growth regulatory control. This is discussed together with the perceived clinical potential of tyrosine kinase inhibitors for the treatment of prostate cancer, when the intracellular signalling, induced by the growth stimulatory factors, can be repressed.
雄激素在促进前列腺生长中起主要作用。双氢睾酮 - 雄激素受体复合物通过与雄激素反应元件结合，特异性地促进这种对基因组的雄激素效应。然而，现在也认识到，这种雄激素介导的信号通路与肽生长因子所促进的信号通路之间存在密切关系，这些通路之间的相互作用对于生长调节控制至关重要。当生长刺激因子诱导的细胞内信号传导可以被抑制时，本文将结合酪氨酸激酶抑制剂在治疗前列腺癌方面的潜在临床应用对此进行讨论。
