Chang M, Saito H, Abe K
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Japan.
Jpn J Pharmacol. 1997 Jul;74(3):281-3. doi: 10.1254/jjp.74.281.
We investigated the effect of cimetidine, a clinically used H2-receptor antagonist, on the induction of long-term potentiation (LTP) in the dentate gyrus of anesthetized rats. Intracerebroventricular injection of cimetidine (50-100 nmol) inhibited the induction of LTP in a dose-dependent manner. The inhibitory effect of cimetidine was not mimicked by other H2-receptor antagonists (ranitidine, famotidine) or the H1-receptor antagonist diphenhydramine or the H3-receptor antagonist thioperamide. These results suggest that cimetidine inhibits hippocampal synaptic plasticity by a novel brain mechanism unrelated to H1, H2 or H3 receptors.
我们研究了临床使用的H2受体拮抗剂西咪替丁对麻醉大鼠齿状回长时程增强（LTP）诱导的影响。脑室内注射西咪替丁（50 - 100 nmol）以剂量依赖的方式抑制LTP的诱导。其他H2受体拮抗剂（雷尼替丁、法莫替丁）、H1受体拮抗剂苯海拉明或H3受体拮抗剂硫代哌丁苯均未模拟西咪替丁的抑制作用。这些结果表明，西咪替丁通过一种与H1、H2或H3受体无关的新的脑机制抑制海马突触可塑性。
