全身性肌束震颤和痉挛后发生的运动神经元病

Motor neuron disease following generalized fasciculations and cramps.

作者信息

Okuda B, Kodama N, Tachibana H, Sugita M

机构信息

Fifth Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

出版信息

J Neurol Sci. 1997 Sep 10;150(2):129-31. doi: 10.1016/s0022-510x(97)00068-3.

DOI:10.1016/s0022-510x(97)00068-3

PMID:9268239

Abstract

We report a case of motor neuron disease in which fasciculations and cramps progressed generally before the development of muscle wasting. After involvement of the upper and lower motor neurons became clinically manifest, widespread fasciculations and cramps persisted and accompanied pseudotetany. The present case suggests that spinal cord pathology of motor neuron disease can cause the abnormal excitability of the motor neurons, resulting in the development of generalized fasciculations and cramps.

摘要

我们报告一例运动神经元病，其中肌束震颤和痉挛通常在肌肉萎缩出现之前就已进展。在上、下运动神经元受累在临床上显现之后，广泛的肌束震颤和痉挛持续存在并伴有假性手足搐搦。本病例提示，运动神经元病的脊髓病理改变可导致运动神经元兴奋性异常，从而引发全身性肌束震颤和痉挛。