Rana Sandeep S, Schramke Carol J, Sangha Amandeep, Karpinski Aryn C
Department of Neurology, Allegheny General Hospital, Pittsburgh; Philadelphia, PA, The Ohio State University, Columbus, OH, USA.
Ann Indian Acad Neurol. 2009 Apr;12(2):108-10. doi: 10.4103/0972-2327.53079.
In this retrospective study, we compared the initial presentation of patients who were eventually diagnosed with either benign fasciculations (BF) or amyotrophic lateral sclerosis (ALS). We found a significantly higher number of patients with BF reporting a past history of psychiatric symptoms, life stressors, and concurrent psychosomatic symptoms. There was no difference between the two groups in patient report of current anxiety or depression symptoms. These findings support our hypothesis that BF are a manifestation of psychological distress due to somatization and that reviewing psychosocial history is important when patients are being evaluated for fasciculations. Patients seeking medical attention for fasciculations and who do not report a history of underlying psychiatric or psychosomatic disorders should be followed closely as fasciculations have been reported to be a presenting feature of ALS.
在这项回顾性研究中，我们比较了最终被诊断为良性肌束震颤（BF）或肌萎缩侧索硬化症（ALS）的患者的初始症状。我们发现，报告有精神症状、生活压力源和并发心身症状既往史的BF患者数量显著更多。两组患者目前焦虑或抑郁症状的报告没有差异。这些发现支持了我们的假设，即BF是躯体化所致心理困扰的一种表现，并且在对有肌束震颤的患者进行评估时，回顾心理社会病史很重要。因肌束震颤寻求医疗关注且未报告有潜在精神或心身疾病史的患者应密切随访，因为据报道肌束震颤是ALS的一种首发特征。
