Tsiperson V P
Department of Vertebrate Zoology & General Ecology, Biological Faculty, Moscow State University, Moscow, 119899, Russia.
Cell Biol Int. 1997 Jun;21(6):359-65. doi: 10.1006/cbir.1997.0135.
No organ equivalent to the bursa of Fabricius in birds, which is responsible for the production of B cells, has been found in mammals thus far. It has been suggested that Peyer's patches and the appendix along with the bone marrow play this role. In this study, the gland of Aselli of shrews was examined, whose function has not yet been clarified. The results of the study of the gland of Aselli in common and water shrews suggest this gland to be the key lymphoid organ analogous to the bursa of Fabricius. However, unlike the bursa of Fabricius, the gland of Aselli seems to fulfil two functions. It not only produces B cells, but also is the site of their terminal differentiation into plasma cells.
迄今为止,在哺乳动物中尚未发现与鸟类法氏囊(负责产生B细胞)相当的器官。有人提出派尔集合淋巴结、阑尾以及骨髓发挥这一作用。在本研究中,对鼩鼱的阿塞利腺进行了检查,其功能尚未明确。对普通鼩鼱和水鼩鼱阿塞利腺的研究结果表明,该腺体是类似于法氏囊的关键淋巴器官。然而,与法氏囊不同的是,阿塞利腺似乎履行两种功能。它不仅产生B细胞,而且还是B细胞终末分化为浆细胞的场所。