Peng Y, Schwarz E J, Lazar M A, Genin A, Spinner N B, Taub R
Department of Genetics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA.
Genomics. 1997 Aug 1;43(3):278-84. doi: 10.1006/geno.1997.4821.
Rat CL-6 is the most highly insulin-induced gene in a liver cell line and is expressed in proliferating liver during regeneration and development. CL-6 is now denoted INSIG1 (insulin-induced gene 1). Human INSIG1 was isolated and found to be 80% identical to the rat gene within the translated region. It was located on human chromosome 7 within band q36. The human INSIG1 promoter conferred a high level of expression in both liver and fibroblast cell lines. INSIG1 expression was upregulated at the transcriptional level in rat regenerating liver and induced in a model of murine adipocyte differentiation, suggesting that INSIG1 may play a role in growth and differentiation of tissues involved in metabolic control.
大鼠CL-6是肝细胞系中胰岛素诱导程度最高的基因，在肝脏再生和发育过程中的增殖肝脏中表达。CL-6现被命名为INSIG1（胰岛素诱导基因1）。人类INSIG1被分离出来，发现在翻译区域内与大鼠基因有80%的同一性。它位于人类7号染色体的q36带内。人类INSIG1启动子在肝脏和成纤维细胞系中均赋予高水平的表达。INSIG1的表达在大鼠再生肝脏的转录水平上上调，并在小鼠脂肪细胞分化模型中被诱导，这表明INSIG1可能在参与代谢控制的组织的生长和分化中发挥作用。
