甲状腺素和丙硫氧嘧啶对胎鼠单胺氧化酶活性的影响

Thyroxine and propylthiouracil-induced changes in the activity of monoamine oxidase in the fetal rat.

作者信息

Gripois D, Fernandez C

出版信息

Mech Ageing Dev. 1977 Nov-Dec;6(6):407-12. doi: 10.1016/0047-6374(77)90042-2.

Abstract

The activity of monoamine oxidase (MAO) towards tryptamine has been determined in heart, brain and liver of the 21.5 day old rat fetus. The activity was compared between normal, thyroxine and propylthiouracil (PTU) treated animals. Hypothyroidism induced by PTU leads to a decrease in the activity of the three organs, while hyperthyroidism causes an increase in the enzymatic activity. These differences seem to be rather independent of the protein content of the organs. It appears thar rat fetal MAO is under a strong thyroid control.

摘要

已测定21.5日龄大鼠胎儿心脏、大脑和肝脏中单胺氧化酶（MAO）对色胺的活性。对正常、经甲状腺素和丙基硫氧嘧啶（PTU）处理的动物的该活性进行了比较。PTU诱导的甲状腺功能减退导致这三个器官的活性降低，而甲状腺功能亢进则导致酶活性增加。这些差异似乎与器官的蛋白质含量关系不大。看来大鼠胎儿MAO受甲状腺的严格控制。