Obadia J F, el Farra M, Bastien O H, Lièvre M, Martelloni Y, Chassignolle J F
Hôpital Cardiologique Louis Pradel, Lyon, France.
J Thorac Cardiovasc Surg. 1997 Aug;114(2):179-85. doi: 10.1016/S0022-5223(97)70142-9.
The aim of the study was to evaluate the prognostic factors for return to sinus rhythm after mitral valve repair.
One hundred ninety-one patients underwent surgery for mitral valve repair, including 142 procedures for valve repair only (74%). The patients with preoperative atrial fibrillation (50.5%) were older, clinically more symptomatic, and had a greater degree of left atrial dilation than the patients who had sinus rhythm.
Preoperative cardiac rhythm, the duration of preoperative atrial fibrillation, and a lesser degree of left atrial hypertrophy are significant prognostic factors independent of the maintenance of sinus rhythm. The probability of return to stable sinus rhythm was 93.7% when sinus rhythm was already present before the operation and 80% when atrial fibrillation was intermittent or of less than 1 year's duration; probability declined abruptly for durations over 1 year. No significant difference in patient survival was noted between those who had sinus rhythm (99% +/- 0.9% at 1 year and 86% +/- 6.6% at 5 years) and those who had atrial fibrillation in the preoperative period (95% +/- 3.1% at 1 year and 86% +/- 8.4% at 5 years). In contrast, the postoperative return to sinus rhythm was associated with 99% +/- 0.9% and 94% +/- 4.8% survivals at 1 and 4 years versus 97% +/- 1.5% and 77% +/- 13% in the event of postoperative atrial fibrillation.
The aim of restoring postoperative sinus rhythm after mitral valve repair should lead to surgery being conducted on patients who have sinus rhythm or recent-onset atrial fibrillation. Surgery for atrial fibrillation may be of value in patients with a long history of atrial fibrillation, providing that it does not induce prohibitive excess mortality.
本研究旨在评估二尖瓣修复术后恢复窦性心律的预后因素。
191例患者接受了二尖瓣修复手术,其中仅进行瓣膜修复的有142例(74%)。术前有房颤的患者(50.5%)比有窦性心律的患者年龄更大,临床症状更明显,左心房扩张程度更大。
术前心律、术前房颤持续时间以及较轻程度的左心房肥厚是独立于窦性心律维持情况的重要预后因素。术前即存在窦性心律时恢复稳定窦性心律的概率为93.7%,房颤为间歇性或持续时间少于1年时为80%;持续时间超过1年时概率急剧下降。术前有窦性心律的患者(1年时为99%±0.9%,5年时为86%±6.6%)与术前有房颤的患者(1年时为95%±3.1%,5年时为86%±8.4%)在患者生存率方面无显著差异。相比之下,术后恢复窦性心律的患者1年和4年生存率分别为99%±0.9%和94%±4.8%,而术后房颤患者为97%±1.5%和77%±13%。
二尖瓣修复术后恢复窦性心律的目标应促使对有窦性心律或近期发生房颤的患者进行手术。对于有长期房颤病史的患者,房颤手术可能有价值,前提是不会导致过高的额外死亡率。