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原发性产后出血的危险因素。一项病例对照研究。

Risk factors for primary postpartum haemorrhage. A case control study.

作者信息

Selo-Ojeme D O, Okonofua F E

机构信息

Department of Obstetrics and Gynaecology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.

出版信息

Arch Gynecol Obstet. 1997;259(4):179-87. doi: 10.1007/BF02505330.

Abstract

The objective of the study was to determine which background factors predispose women to primary postpartum haemorrhage (PPH) at the Obafemi Awolowo University Hospital. The study consisted of 101 women who developed PPH after a normal vaginal delivery and 107 women with normal unassisted vaginal delivery without PPH Both cases and controls were investigated for sociodemographic risk factors, medical and obstetric histories, antenatal events and labour and delivery outcomes. Data were abstracted from the medical and delivery records and risks were estimated by multivariate logistic regression. The results of the univariate analysis revealed a number of potential risk factors for PPH but after adjustment by logistic regression three factors remained significant. These were prolonged second and third stages of labour and non-use of oxytocics after vaginal delivery. Previously hypothesised risk factors for PPH such as grand multiparity, primigravidity and previous episodes of PPH were not significantly associated with PPH. We conclude that primary PPH in this population is mostly associated with prolonged second and third stages of labour and non use of oxytocics. Efforts to reduce the incidence of PPH should not only be directed at proper management of labour but also training and retraining of primary health care workers and alternative health care providers in the early referral of patients with prolonged labour.

摘要

该研究的目的是确定在奥巴费米·阿沃洛沃大学医院,哪些背景因素使女性易患原发性产后出血(PPH)。该研究包括101名正常阴道分娩后发生PPH的女性和107名正常无辅助阴道分娩且未发生PPH的女性。对病例组和对照组均调查了社会人口统计学风险因素、医疗和产科病史、产前情况以及分娩结局。数据从医疗和分娩记录中提取,并通过多因素逻辑回归估计风险。单因素分析结果显示了一些PPH的潜在风险因素,但经逻辑回归调整后,有三个因素仍然显著。这些因素是第二和第三产程延长以及阴道分娩后未使用催产剂。先前假设的PPH风险因素,如多产、初产和既往PPH发作,与PPH无显著关联。我们得出结论,该人群中的原发性PPH主要与第二和第三产程延长以及未使用催产剂有关。降低PPH发生率的努力不仅应针对产程的妥善管理,还应针对对初级卫生保健工作者和替代卫生保健提供者进行培训和再培训,使其能在产程延长的患者早期转诊方面发挥作用。

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