经皮硝酸甘油：更换贴片及应用部位的临床和药代动力学影响。
Transdermal nitroglycerin: clinical and pharmacokinetic consequences of renewing the patch and the application site.
作者信息
Klemsdal T O, Mundal H H, Bredesen J E, Gjesdal K
机构信息
Department of Cardiology, Ullevål University Hospital, Oslo, Norway.
出版信息
Eur J Clin Pharmacol. 1997;52(5):379-81. doi: 10.1007/s002280050304.
OBJECTIVE
We examined whether nitroglycerin (glyceryl trinitrate, GTN) patch treatment for 24 h could induce local cutaneous changes that impaired drug delivery and clinical efficacy.
METHODS
Twenty angina patients were exercise-tested after 2 and 24 h of treatment and then 2 h after patch renewal. The patch was either renewed on a new skin location or on the previous application site in a randomised, double-blind, cross-over protocol. GTN plasma concentrations and finger plethysmography were obtained before and after each exercise test.
RESULTS AND CONCLUSIONS
The clinical efficacy, the effect seen on plethysmography and the GTN plasma concentrations tended to increase after patch renewal, regardless of the application site of the renewed patch. Hence, cutaneous changes of clinical importance could not be demonstrated.
目的
我们研究了硝酸甘油（三硝酸甘油酯，GTN）贴片治疗24小时是否会引起局部皮肤变化，从而损害药物递送和临床疗效。
方法
20名心绞痛患者在治疗2小时和24小时后以及贴片更换后2小时进行运动测试。贴片以随机、双盲、交叉方案在新的皮肤部位或先前的应用部位进行更换。在每次运动测试前后测量GTN血浆浓度和手指体积描记法。
结果与结论
无论更换后的贴片应用部位如何，贴片更换后临床疗效、体积描记法显示的效果和GTN血浆浓度均有增加趋势。因此，未发现具有临床意义的皮肤变化。
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