经皮硝酸酯类药物治疗：在每日更换贴片后，运动期间的生物利用度会短暂增加。
Transdermal nitrate therapy: bioavailability during exercise increases transiently after the daily change of patch.
作者信息
Gjesdal K, Klemsdal T O, Rykke E O, Bredesen J E
机构信息
Oslo University Hospital Ullevål, Department of Cardiology, Norway.
出版信息
Br J Clin Pharmacol. 1991 May;31(5):560-2. doi: 10.1111/j.1365-2125.1991.tb05582.x.
Abstract
Ten volunteers carried a 10 mg 24 h -1 transdermal glyceryl trinitrate (GTN) patch for 24 h before moderate exercise. Plasma GTN-concentration increased significantly (P less than 0.05) by 19% to peak value at 15 min. Two hours after patch renewal repeat exercise increased GTN concentration by 56% (P less than 0.001). The two nitrate-concentration curves differed significantly (P less than 0.0001). Thus, change of patch augmented nitrate availability during exercise.
摘要
十名志愿者在进行适度运动前24小时佩戴10毫克/24小时的经皮硝酸甘油（GTN）贴片。血浆GTN浓度在15分钟时显著增加（P<0.05），增幅达19%，达到峰值。更换贴片两小时后，重复运动使GTN浓度增加了56%（P<0.001）。两条硝酸盐浓度曲线差异显著（P<0.0001）。因此，更换贴片增加了运动期间硝酸盐的可用性。
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