Hui Y, Hao Y, Chen X, Jing S, Dai Z
Department of Cardiovascular Medicine, Electric Power General Hospital, Beijing.
Chin Med J (Engl). 1996 Nov;109(11):885-7.
To evaluate the relationship between certain humoral factors and left ventricular hypertrophy (LVH) in essential hypertension.
62 essential hypertension (EH) patients (32 men, 30 women; mean age, 55 years) and 20 normotensive healthy subjects (10 men, 10 women: mean age, 52 years) were studied. EH patients were divided into LVH group and non-LVH group by echocardiography. After an overnight fast, blood samples were taken for the determination of parathyroid hormone (PTH), angiotensin II (ATII) and aldosterone (ALD) by radioimmunoassay.
There was a significant difference in PTH. AT II and ALD between the EH group and control group. Furthermore, in LVH group PTH, ATII and ALD elevated significantly as compared with non-LVH group. In addition, we found that LVMI (left ventricular mass index) correlated with ATII (r = 0.342, P < 0.01) and ALD (r = 0.356, P < 0.01). There was a more significant correlation between LVMI and PTH (r = 0.422, P < 0.0025).
Some humoral factors are important determinants of LV mass. Besides the reninangiotensin-aldosterone system, PTH might play an important role in cardiac hypertrophy.
评估原发性高血压患者某些体液因子与左心室肥厚（LVH）之间的关系。
研究了62例原发性高血压（EH）患者（男性32例，女性30例；平均年龄55岁）和20例血压正常的健康受试者（男性10例，女性10例；平均年龄52岁）。通过超声心动图将EH患者分为LVH组和非LVH组。过夜禁食后，采集血样，采用放射免疫分析法测定甲状旁腺激素（PTH）、血管紧张素II（ATII）和醛固酮（ALD）。
EH组与对照组之间的PTH、AT II和ALD存在显著差异。此外，LVH组的PTH、ATII和ALD与非LVH组相比显著升高。此外，我们发现左心室质量指数（LVMI）与ATII（r = 0.342，P < 0.01）和ALD（r = 0.356，P < 0.01）相关。LVMI与PTH之间的相关性更显著（r = 0.422，P < 0.0025）。
某些体液因子是左心室质量的重要决定因素。除肾素 - 血管紧张素 - 醛固酮系统外，PTH可能在心脏肥大中起重要作用。
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