Chen O, Guan G, Jin C
Second Affiliated Hospital, Bethune University of Medical Sciences, Changchun.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1996;31(1):43-6.
Laryngeal carcinoma-associated antigens in tissue and serum of patients with laryngeal carcinoma and normal adults were detected by using ABC and ELISA methods. The results showed that the positive rate rised from 80-86.6% to 97.7% by applying mixed monoclonal antibodies compared with single monoclonal antibody against laryngeal cancer. It was also found that the level of laryngeal carcinoma-associated antigens was much higher in serum of laryngeal carcinoma group than that of control group. The statistic difference was very significant (P < 0.01). The level was different with clinical types, stages and increased in line with the tumor growth. So it was suggested that the mixed monoclonal antibodies were sensitive and specific, which was considered as a useful tumor marker for diagnosis, monitoring clinial course and judging prognosis of patient with laryngeal carcinoma.
采用ABC法和ELISA法检测喉癌患者及正常成年人组织和血清中的喉癌相关抗原。结果显示，与单一抗喉癌单克隆抗体相比，应用混合单克隆抗体后阳性率从80% - 86.6%提高到97.7%。还发现喉癌组血清中喉癌相关抗原水平明显高于对照组。统计学差异非常显著（P < 0.01）。该水平随临床类型、分期不同而有所差异，并随肿瘤生长而升高。因此提示混合单克隆抗体敏感且特异，可作为喉癌患者诊断、监测病程及判断预后的有用肿瘤标志物。
