Zhang S, Yu L, Qiu H
Department of Internal Medicine, First Affiliated Hospital, Chongqing University of Medical Sciences.
Zhonghua Yi Xue Za Zhi. 1996 Jun;76(6):435-9.
To discuss the inheritant mode of familial NIDDM.
According to WHO criteria of DM, 100 NIDDM Probands with family history of DM were diagnosed and 100 persons were chosen at random for controls. The survey of DM was performed in both groups, including FBG, HbAlc, FINS. Some members had insulin release test.
The prevalance rates of DM in familial DM group were 26 times of the control group (34.3% and 1.3%). The prevalance rate of DM among first-degree relation was 18 times higher than that in general population (28.3% and 1.5%). The rate of diabetes in the siblings and in the off-springs was 44.4% and 9.7% respectively. The pedigree analyses showed that 83.9% affected families had one diabetic parent, one half siblings had DM, and there was a successive transmission of DM through at least three generations in sixteen large families. Besides, the incidence of DM was much higher in females than in males (40% and 28%). Among affected parents, diabetlic mothers were much more than diabetic fathers (50.8% and 27.6% P < 0.01).
Familial NIDDM had a familial aggregation. It was inherited in the manner of Mendelian autosomal dominant inheritance. The difference between the rate in DM mothers and fathers was probably due to unequal prevalance rate in females and males.
探讨家族性非胰岛素依赖型糖尿病（NIDDM）的遗传方式。
根据世界卫生组织（WHO）糖尿病诊断标准，对100例有糖尿病家族史的NIDDM先证者进行诊断，并随机选取100人作为对照。对两组进行糖尿病调查，包括空腹血糖（FBG）、糖化血红蛋白（HbAlc）、空腹胰岛素（FINS）。部分成员进行胰岛素释放试验。
家族性糖尿病组的糖尿病患病率是对照组的26倍（34.3%和1.3%）。一级亲属中的糖尿病患病率比普通人群高18倍（28.3%和1.5%）。兄弟姐妹和后代的糖尿病患病率分别为44.4%和9.7%。系谱分析显示，83.9%的患病家庭有一位糖尿病父母，一半的同胞患有糖尿病，并且在16个大家庭中糖尿病至少连续传递了三代。此外，女性糖尿病的发病率远高于男性（40%和28%）。在患病父母中，患糖尿病的母亲比患糖尿病的父亲多得多（50.8%和27.6%，P<0.01）。
家族性NIDDM具有家族聚集性。它以孟德尔常染色体显性遗传方式遗传。糖尿病母亲和父亲患病率的差异可能是由于女性和男性患病率不同所致。
