Deo Sonali S, Gore S D, Deobagkar D N, Deobagkar Deepti D
Molecular Biology Research Laboratory, Department of Zoology University of Pune, India.
J Assoc Physicians India. 2006 Jun;54:441-4.
To study the inheritance pattern of diabetes mellitus in Western Indian population by analysing the pedigree of diabetes patients.
3,921 individuals from 300 families were interviewed for family history in this study, out of which 770 were diabetic individuals. Statistical analysis of the data was carried out using T-test and Chi-square test.
37% cases of Type 1 DM and 58% cases of Type 2 DM showed family history of the disease. Of the cases showing family history for diabetes, 92% in case of Type 1 DM and 59% in case of Type 2 DM showed family history of Type 2 DM with a decrease in age of onset in the successive generations. Both the parents, when diabetic conferred equal risk of inheriting diabetes in offspring. The sex ratio of offspring suffering from diabetes was not influenced when only one of the parents was diabetic. However it was observed that the male offspring were highly susceptible when both parents were diabetic (Chi-square value=4.55 with 1 d.f.). The age of onset of diabetes did not show significant correlation with whether one or both the parents were diabetic. However, it was noteworthy that in case of familial history of diabetes there was a decrease in the age of onset in successive generations.
This study suggests that family history of diabetes results in predisposition to early onset of the disease in successive generations and a cluster of genes involved in Type 2 DM may show a parental effect for predisposition to Type 1 DM in the offspring in this set of Indian population.
通过分析糖尿病患者的家系，研究西印度人群中糖尿病的遗传模式。
本研究对300个家庭的3921人进行了家族史访谈，其中770人为糖尿病患者。使用t检验和卡方检验对数据进行统计分析。
1型糖尿病患者中有37%、2型糖尿病患者中有58%有家族病史。在有糖尿病家族史的病例中，1型糖尿病患者中有92%、2型糖尿病患者中有59%有2型糖尿病家族史，且发病年龄在连续几代中呈下降趋势。父母双方患糖尿病时，其子女患糖尿病的风险相同。当父母一方患糖尿病时，子女患糖尿病的性别比例不受影响。然而，观察到父母双方都患糖尿病时，男性后代极易患病（卡方值=4.55，自由度为1）。糖尿病的发病年龄与父母一方或双方是否患糖尿病无显著相关性。然而，值得注意的是，在有糖尿病家族史的情况下，发病年龄在连续几代中呈下降趋势。
本研究表明，糖尿病家族史会导致连续几代人易患该疾病的早发，并且在这组印度人群中，与2型糖尿病相关的一组基因可能对后代患1型糖尿病具有亲本效应。
