Dahmen N, Fehr C, Reuss S, Hiemke C
Department of Psychiatry, University of Mainz, Germany.
Biol Psychiatry. 1997 Sep 1;42(5):317-23. doi: 10.1016/S0006-3223(96)00361-7.
The stimulation of immediate early gene expression in brain and neuronal cell culture systems has been reported after various experimental paradigms such as chemiconvulsant-provoked seizures or specific drug applications. In particular, the induction of immediate early genes by adrenergic model substances has been demonstrated by several investigators. This report demonstrates that a single dose of desipramine (10 or 25 mg/kg), a classical tricyclic antidepressant drug acting on the adrenergic system, induced c-fos and zif268 expression in rat hippocampus without affecting c-jun. The observed immediate early gene response might reflect part of a signal transduction cascade involved in long-term neuroadaptive and behavioral changes after antidepressant drug treatment.
在各种实验范式下，如化学惊厥诱发的癫痫发作或特定药物应用后，大脑和神经元细胞培养系统中即刻早期基因表达的刺激已被报道。特别是，几位研究者已证明肾上腺素能模型物质可诱导即刻早期基因。本报告表明，单剂量的地昔帕明（10或25毫克/千克），一种作用于肾上腺素能系统的经典三环抗抑郁药，可诱导大鼠海马体中的c-fos和zif268表达，而不影响c-jun。观察到的即刻早期基因反应可能反映了抗抑郁药物治疗后长期神经适应性和行为变化所涉及的信号转导级联反应的一部分。
